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Product ID: 11397

Doctor's Best SAMe 200 60 tabs - 200 mg

  • N101 Price: $21.89
  • MSRP: $39.99
  • SAVE: $18.10 (45%)
  • Buy 3 for $20.39 each and save 49%
Special Order Item
Special Order Items
  • These are non-stock items which are ordered specifically for your order.
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  • We cannot accept the return of special order items without a return authorization. You must call Customer Service at 1-866-438-6101 to receive a return authorization.
  • Once we have ordered these items from the manufacturer, we cannot cancel the items. We generally order such items within 24 hours after you place your order, so please call immediately if you need to cancel.
  • If a return or cancellation is authorized, a 25% restocking fee may apply.
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Product Highlights

  • 200 mg Active S-Adenosyl Methionine Per Tablet
  • Pharmaceutical Grade Made in Italy
  • Enhances Mood & Neural Function
  • Promotes Joint Comfort & Mobility
  • Supports Liver Health & Detoxification
  • Sealed in Blister Packs for Freshness & Convenience

Product Description


Our SAMe 200 contains 200 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.


S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.


Supplementing with SAMe


The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 200 is processed to yield the highest available percentage of the active pure S,S form on the market.


SAMe and Joint Function


SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.*


SAMe and Neural Health


SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.


SAMe and Liver Function


SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

Supplement Facts
Serving Size: 1 Tablet
Servings Per Container: 60
  Amount Per Serving % Daily Value*
  S-Adenosyl Methionine
(from 400 mg of SAM-etosylate disulfate)
200  mg ** 
*Percent Daily Values are based on a 2,000 calorie diet.
**Daily Value not established.

Other Ingredients:

Cellulose gel, methacrylic acid copolymer, comprtol 888ATO, talc, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silica, medium chain triglycerides, sodium glycolate and iron oxide.

Does Not contain: milk, egg, wheat, corn, sugar, sweeteners, or preservatives.

Additional Information

Weight 0.3000
Product Notes Suitable for Vegetarians

Contains nothing other than listed ingredients.

SAM-e has an excellent safety profile and is considered well-suited for long term use based on multiple clinical trials.
Suggested Use Take 1 tablet daily away from food, or as directed by a health care professional. Do not chew or crush tablet.

Individuals diagnosed with manic depression should avoid SAM-e supplementation, as it may aggravate the manic phase.
Product Warnings Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.
Product Size 60 tabs - 200 mg
UPC 753950002067

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

The products and the claims made about specific products on or through this site have not been evaluated by N101, Inc. or the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. Information about each product is taken from the labels of the products or from the manufacturer's advertising material. N101 is not responsible for any statements or claims that various manufacturers make about their products. We cannot be held responsible for typographical errors or product formulation changes.